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期刊
- 作者：
Xijing Zhang ，Yu Chen ，Renhuai Liu ，Wei Fang ，Bingyu Qin ，Ronglin Jiang ，Yuan Gao ，Wenxiong Li ，Jianfeng Wu ，Mingyan Zhao ，Yi Yang ，Xiaochun Ma ，Bin Du ，Jiao Liu ，Xuan Song ，Dong Zhang ，Xinjing Gao ，Xiaodong Jin ，Jian Liu ，Fen Liu ，Lixia Liu ，Jinghui Li ，Siqing Ma ，Zhiyong Peng ，Yunbo Sun ，Songjing Shi ，Feng Shen ，Huanzhang Shao ，Tiehe Qin ，XianYao Wan ，Jinquan Wang ，Hongliang Wang ，Weidong Wu ，Haiying Wu ，Fang Xu ，Bin Xiong ，Xiangyou Yu ，Xiaojun Yang ，Lina Zhang ，Hongsheng Zhao ，Lipeng Zhang ，Xiangdong Guan ，Yan Kang & …Dechang Chen （ 1Department of Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xian, China;2Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China;3Henan Provincial People’s Hospital, Zhengzhou, China;4Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou, 310006, zhejiang, China;5Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;6Affiliated Beijing Chaoyang Hospital of Capital Medical University, Beijing, China;7Department of Guangdong Clinical Research Center for Critical Care Medicine, The first Affiliated Hospital of Sun Yat-sen University, Guangdong, 510080, China;8The First Affiliated Hospital of Harbin Medical University, Harbin, China;9Zhongda Hospital Southeast University, Nanjing, China;10The First Affiliated Hospital of China Medical University, Shenyang, China;11Peking Union Medical College Hospital, Beijing, China;12Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China;13Public Health Clinical Center Affiliated to Public Health Clinical Center, Shandong University, Jinan, Shandong, China;14The First Hospital of Jilin University, Changchun, China;15Tianjin University Central Hospital, Tianjin, China;16West China Hospital, Sichuan University, Chengdu, China;17Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China;18Gansu Provincial Central Hospital, Lanzhou, China;19The First Affiliated Hospital of Nanchang University, Nanchang, China;20The Fourth Hospital of Hebei Medical University, Shijiazhuang, China;21Haikou Municipal People’s Hospital, Haikou, China;22Qinghai Provincial People’s Hospital, Xining, China;23Zhongnan Hospital of Wuhan University, Wuhan, China;24Cheeloo College of Medicine, Qilu Hospital (Qingdao), Shandong University, Jinan, China;25Fuzhou University Affiliated Fujian Provincial Hospital, Fuzhou, China;26The Affiliated Hospital of Guizhou Medical University, Guiyang, China;27Guangdong Provincial People’s Hospital, Guangzhou, China;28The First Affiliated Hospital of Dalian Medical University, Dalian, China;29The First Affiliated Hospital of USTC, Hefei, China;30The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China;31Bethune Hospital of Shanxi Province, Taiyuan, China;32The First Affiliated Hospital of Kunming Medical University, Kunming, China;33The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;34The People’s Hospital of Guangxi Zhuang Autonomous Region(Guangxi Academy of Medical Sciences), Nanning, China;35The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China;36General Hospital of Ningxia Medical University, Yinchuan, China;37Xiangya Hospital of Central South University, Changsha, China;38Affiliated Hospital of Nantong University, Nantong, China;39The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China;40West China Tianfu Hospital, Sichuan University, Chengdu, 610299, Sichuan, China ） - 出处： Critical Care
- 关键词： Critical Care Resource Nationwide Survey China
- 摘要： Background Critical care medicine plays a pivotal role in addressing life-threatening conditions; however, its development in China is hindered by re
期刊
- 作者：
Min Zhou ，Yuanqing Cao ，Ke Yue ，Wenyu Wu ，Yutong Xie ，Daiyu Hu ，Jingjing Zhao ，Fang Xu ，Jianrong Guo ，Zhenzhou Li ，Huan Wang ，Zhengliang Gao （ Clinical Research Center for Mental Health, Mental Health Center Affiliated to School of Medicine (Shanghai Hongkou Mental Health Center), Shanghai University；Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University；Department of Anesthesiology, Gongli Hospital of Shanghai Pudong New Area ） - 出处： Neural Regeneration Research 2026 第7期
- 关键词： brain disorder brain organoid CRISPR/Cas9 disease modeling drug screening genome editing human brain development lineage tracing organoid modeling stem cell differentiation
- 摘要： Brain organoids are artificial neural tissues derived in vitro, containing a variety of cell types, as well as structural and/or functional brain regi
期刊
- 作者：
Min Zhou ，Yuanqing Cao ，Ke Yue ，Wenyu Wu ，Yutong Xie ，Daiyu Hu ，Jingjing Zhao ，Fang Xu ，Jianrong Guo ，Zhenzhou Li ，Huan Wang ，Zhengliang Gao （ Clinical Research Center for Mental Health, Mental Health Center Affiliated to School of Medicine (Shanghai Hongkou Mental Health Center), Shanghai University；Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University；Department of Anesthesiology, Gongli Hospital of Shanghai Pudong New Area；Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University；School of Basic Medicine, Medical Genetics and Cell Biology, Ningxia Medical University；China-Japan Friendship Medical Research Institute, School of Medicine ） - 出处： Neural Regeneration Research 2026 第7期
- 关键词： brain disorder brain organoid CRISPR/Cas9 disease modeling drug screening genome editing human brain development lineage tracing organoid modeling stem cell differentiation
- 作者：
张竞文 ，于兵 ，徐方 ，李亚宁 ，胡以平 （ 宁夏医科大学基础医学院代谢性心血管疾病研究重点实验室；海军军医大学细胞生物学教研室 ） - 出处： 西安交通大学学报(医学版) 2023 第4期
- 关键词： 毛状分裂增强子1 肝干细胞 分化 胆管细胞 角蛋白19 谷胱甘肽合成酶 肝核因子1β
- 摘要： 目的 探讨毛状分裂增强子1调控肝干细胞向胆管细胞分化的作用。方法 将p TRE2hyg-Hes1和p TRE2hyg-EGFP-Hes1转染LEPCs,不同浓度强力霉素诱导Hes1的表达。通过Western blotting、PCR、RT-PCR、Real-time PCR、免疫细胞化学和免疫荧光
- 作者：
李昕 ，徐方 ，胡蓉 ，马会明 ，王蒙蒙 ，王永峰 ，相丽 ，马璐 （ 宁夏医科大学生育力保持教育部重点实验室；宁夏医科大学生育力保持教育部重点实验室；宁夏医科大学总医院生殖医学中心 ） - 出处： 中华医学会第十次全国生殖医学学术会议 2016 中华医学会第十次全国生殖医学学术会议论文集
- 会议录： 中华医学会第十次全国生殖医学学术会议论文集
- 作者：
隋御 ，王媛 ，李元杰 ，彭亮 ，徐方 （ 宁夏医科大学基础医学院；宁夏医科大学生育力保持教育部重点实验室；宁夏医科大学总医院 ） - 出处： 宁夏医科大学学报 2022 第10期
- 关键词： polι基因 奥沙利铂 结肠癌细胞 细胞增殖 细胞凋亡
- 摘要： 目的 研究DNA聚合酶ι基因对人类结肠癌化疗药物奥沙利铂敏感性的影响。方法 采用RNAi技术使SW480细胞中polι基因的表达降低，通过Real time PCR实验检测基因polι低表达水平；运用MTT实验确定SW480细胞对药物奥沙利铂的敏感性确定给药剂量，并设立实验分组；分别使用流式细胞术和
期刊
- 作者：
Li, Tingting ，Zhou, Hao ，Ma, Jiahua ，Lin, Dong ，Xu, Fang ，Fu, Xueyan （ 1 Ningxia Medical University, Yinchuan, China; Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education (Ningxia Medical University), Yinchuan, China 2 Ningxia Medical University, Yinchuan, China; School of Pharmacy, Ningxia Medical University, Yinchuan, China 3 Ningxia Medical University, Yinchuan, China 4 Ningxia Medical University, Yinchuan, China; Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education (Ningxia Medical University), Yinchuan, China; School of Pharmacy, Ningxia Medical University, Yinchuan, China ） - 出处： Evidence - Based Complementary and Alternative Medicine 2021 Vol.2021
- 摘要： Licorice is a commonly used traditional Chinese medicine and natural sweetening agent, rich in numerous bioactive compounds. Moreover, it is one of th
- 作者：
Ma, Lu ，Li, Xin ，Zhao, Xiaopeng ，Sun, Haotong ，Kong, Feifei ，Li, Yuanjie ，Sui, Yu ，Xu, Fang （ 1 Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China 2 Key Laboratory of Reproduction and Genetics, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China 3 Department of Oncology, Qufu People's Hospital, Qufu, Shandong 273100, P.R. China ） - 出处： Molecular Medicine Reports 2021 Vol.24 No.3
- 关键词： cell apoptosis colon cancer cell mitotic arrest deficient 2 like 2 oxaliplatin ubiquitin-proteasome pathway
- 摘要： The clinical efficacy of colorectal tumor treatment is restricted due to platinum agent resistance. Translesion DNA synthesis has been shown to contr
- 作者：
Ma, Lu ，Li, Xin ，Zhao, Xiaopeng ，Sun, Haotong ，Kong, Feifei ，Li, Yuanjie ，Sui, Yu ，Xu, Fang （ Affiliations: 1: Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China 2: Department of Oncology, Qufu People's Hospital, Qufu, Shandong 273100, P.R. China ） - 出处： Molecular Medicine Reports 2021 Vol.24 No.3 P1-9
- 摘要： The clinical efficacy of colorectal tumor treatment is restricted due to platinum agent resistance. Translesion DNA synthesis has been shown to contr
- 作者：
张竞文 ，党洁 ，焦海燕 ，徐方 （ 宁夏医科大学基础医学院医学遗传与细胞生物学教研室 ） - 出处： 基础医学教育 2021 第8期
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被引量：4
- 徐方，女，1962年5月生，中共党员，二级教授，博士研究生导师。现任研究生院院长，兼任生育力保持教育部重点实验室副主任；国家自然科学基金项目和“863”项目评审专家；担任中国学位与研究生教育学会医药科工作委员会理事、宁夏科学技术协会常委、宁夏侨联常委、宁夏生物学会副理事长、中国遗传学会理事、中国细胞生物学会理事、宁夏分子检测学会常务理事等；为《国际遗传学杂志》、《中国细胞生物学学报》、《中华医药杂志》、《宁夏医科大学学报》等学术刊物的编委。长期从事医学遗传学教学与科研工作，主要研究方向为“DNA损伤修复与肿瘤发生发展的关系”，主持5项国家自然科学基金项目及十余项省部级重要科研课题的研究，曾获国家卫生部科技进步三等奖1项、自治区科技进步二/三等奖6项，发表及合作发表专业论文70余篇，合著英文专著1部；为自治区教学名师（2009年），主持教改项目并获自治区教学成果特等奖1项（2013年）。入选国家“百千万人才工程”第三层次（1998年）、享受自治区政府特殊津贴（2006年）和国务院政府特殊津贴（2008年）、获全国“五一”劳动奖章（2006年）、获自治区“塞上英才”（2015年）、评为全国优秀科技工作者（2016年）、获得西部突出贡献奖（2008年），两次荣获中国侨界创新人才奖（2010年、2012年）、荣获自治区“五四”青年奖章（2001年）、评为中国学位与研究生教育学会医药科工作委员会优秀工作者（2017年）等。