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期刊
- 作者:
Guo, Sheng-Nan ,Li, Xin-Xiao ,Wang, Feng ,Liu, Kun-Mei ,Ding, Na ,Hu, Qi-Kuan ,Sun, Tao ( aDepartment of Physiology, Basic Medical School of Ningxia Medical University, Yinchuan, 750004, China;bNingxia Key Laboratory of Cerebrocranial Diseases, Yinchuan, 750004, China;cDepartment of Neurosurgery, General hospital of Ningxia Medical University, Yinchuan, 750004, China ) - 出处: China Biotechnology 2020 Vol.40 No.3 P9-20
- 关键词: Cre/Loxp epilepsy with ebrile eizures plus GABRG2 Gene knockout Genetic Neocortex and hippocampus recombination system
- 摘要: To establish and identify the neocortex and hippocampus specific GABAA receptor γ2 subunit knockout mice via Cre/Loxp conditional gene knockout techn
- 作者:
康亚莉 ,扈启宽 ,宁唤唤 ,周洁 ,任瑞 ,康健 ,路延之 ,韦垠 ,高晓菁 ,张琳娜 ,柏银兰 ( 1宁夏医科大学基础医学院;2空军军医大学基础医学院微生物与病原生物学教研室;3空军军医大学西京医院内分泌科 ) - 出处: 解放军医学杂志 2023 第48卷 第7期 P768-775
- 关键词: 卡介苗 1型糖尿病 免疫治疗
- 摘要: 目的 评价卡介苗对1型糖尿病小鼠的免疫治疗效果,并探索其作用机制。方法 将15只SPF级雄性C57BL/6小鼠随机分为造模组与对照组;取造模成功即随机血糖≥16.7 mmol/L的10只小鼠分为T1DM组与卡介苗组。随后BCG组小鼠经皮下注射BCG 1×106 cfu/只进行免疫治疗,4周后加强免疫
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被引量:4
- 作者:
罗彦 ,聂黎虹 ,胡淑婷 ,张琳娜 ,扈启宽 ,彭涛 ,王银 ( 宁夏医科大学基础医学院生理学与神经生物学系 ) - 出处: 基础医学教育 2022 第9期
- 关键词: 生理学 留学生教学 教学改革 线上教学
- 摘要: 为提高留学生生理学线上教学理论教学和实验教学的质量,文章通过重构教学内容结合拓展性学习,优化教学设计,布置以掌握重点、难点为目的的课后作业以帮助学生掌握基本知识点,结合问卷星推送临床相关练习题以培养学生分析问题的能力,推送相关知识点的科研论文以促进学生拓展性学习,重构实验课教学目标和内容以提高实验教
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被引量:2
- 作者:
陈章平 ,李信晓 ,郭胜楠 ,孙涛 ,扈启宽 ( 宁夏医科大学宁夏颅脑疾病重点实验室;郑州大学第五附属医院神经外科;郑州大学第五附属医院康复医学科;宁夏医科大学基础医学院 ) - 出处: 宁夏医科大学学报 2022 第7期
- 关键词: GABRG2基因 基质金属蛋白酶 基因敲除 癫痫 小鼠 HT22细胞
- 摘要: 目的 探究GABRG2基因敲除后小鼠海马和HT22细胞中基质金属蛋白酶3的表达变化及潜在参与机制。方法 动物实验:利用Cre/loxp重组酶系统所构建的GABA受体γ2亚基基因条件性敲除小鼠模型为实验组,野生型小鼠作为对照组,用Western blot技术检测小鼠海马中GABRG2、PKA、p-PK
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被引量:4
- 作者:
张琳娜 ,纪文武 ,李宏辉 ,扈启宽 ( 宁夏医科大学基础医学院生理学系;宁夏医科大学研究生院;宁夏医科大学临床医学院 ) - 出处: 科教导刊 2022 第4期
- 关键词: 硕士研究生 生理学专业课 课程思政
- 摘要: 研究生教育是国民教育的重要组成部分,在培养高层次创新人才方面具有既直接又基础的重要意义。立德树人是教育的根本任务,全面推进课程思政建设,贯穿于课堂授课、教学研讨、实验实训、作业论文等各环节。分析生理学硕士研究生专业课的课程特点,梳理教学内容,从中找到课程思政的元素,恰如其分地融入课堂教学中,达到润物
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被引量:4
期刊
- 作者:
Zhang, Linna ,Cao, Huimei ,Tao, Hong ,Yang, Jijuan ,Gong, Wei ,Hu, Qikuan ( 1 Department of Physiology, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China 2 Department of Orthopedics, Ningxia People's Hospital, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China 3 Ningxia Key Laboratory of Cerebrocranial Diseases, Basic Medical School of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China ) - 出处: Experimental & Therapeutic Medicine 2021 Vol.22 No.1
- 关键词: DRP1 glioma stem cells mitochondrial fission
- 摘要: In the present study, a model of glioma stem cells was established and combined with molecular targeting drugs in order to observe its inhibitory eff
期刊
- 作者:
Wang, Yang-Kai ,Yu, Qiang ,Tan, Xing ,Wu, Zhao-Tang ,Zhang, Ru-Wen ,Yang, Ya-Hong ,Yuan, Wen-Jun ,Hu, Qi-Kuan ,Wang, Wei-Zhong ( a Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, China; b Department of Physiology, Key Lab of Ministry of Education in Fertility Preservation and Maintenance, Ningxia Medical University, Yinchuan, 750004, China ) - 出处: Journal of Hypertension 2016 Vol.34 No.5 P993-1004
- 关键词: angiotensin II centrally antihypertensive mechanism hypertension lentivirus oxidative stress.
- 摘要: Objective: Centrally acting antihypertensive action of moxonidine is a result of activation of Imidazoline-1 receptor in the rostral ventrolateral me
- 作者:
王峰 ,孙涛 ,刘诤 ,宋子木 ,刘阳 ,扈启宽 ,张庆 ,王万弟 ,郭玉林 - 关键词: 岛叶 癫痫 手术治疗 皮质 相关疾病 治疗学
- 摘要: 岛叶功能复杂神秘,与多种神经精神类疾病以及认知功能关系密切,对岛叶功能学的研究,正成为脑科学研究的一个热点。岛叶是多种疾病的好发部位,岛叶区域病变的手术治疗也是神经外科难度最大、最具挑战性的手术之一。癫痫是神经系统常见疾病,岛叶起源或岛叶受累是难治性癫痫手术治疗失败的一个重要原因。深入研究岛叶功能,
- 作者:
Gao, Ting ,Zhang, Shao-Ping ,Wang, Jian-Fei ,Liu, Li ,Wang, Yin ,Cao, Zhi-Yong ,Hu, Qi-Kuan ,Yuan, Wen-Jun ,Lin, Li ( a Department of Physiology and Key Lab of Ministry of Education in Fertility Preservation and Maintenance, Ningxia Medical University, Yinchuan, China; b Department of Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; c Department of Ultrasound, Shanghai Punan Hospital, Shanghai, China; d Ultrasound Department of Shanghai Pulmonary Hospital, Tongji University, Shanghai, China; e Department of General Internal Medicine, Branch of 411 Hospital of People's Liberation Army, Shanghai, China; f Department of Physiology, Second Military Medical University, Shanghai, China ) - 出处: Journal of Cellular and Molecular Medicine 2018 Vol.22 No.1 P395-408
- 关键词: autophagy heart failure myocardial infarction toll-like receptor
- 摘要: Toll-like receptors are essential immunoreceptors involved in host defence against invading microbes. Recent studies indicate that certain TLRs activ
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期刊
- 作者:
Chen, Ling ,Huang, Jie ,Li, Xiao-Cheng ,Liu, Si-Yang ,Li, Yun-Hong ,Wang, Qiang ,Yang, Ji-juan ,Cao, Hui-Mei ,Hu, Qi-Kuan ,He, Lan-Jie ( Department of Physiology, Ningxia Medical University, Yinchuan, Ningxia, P. R. China Endocrine Testing Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, P. R. China Department of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, P. R. China Department of Endocrinology, the First Affiliated Hospital of Xi'an Medical University, Xi'an, Shanxi, P. R. China Department of Endocrinology, Ningxia People's Hospital, Yinchuan, Ningxia, P. R. China Medical Science and Technology Research Center, Ningxia Medical University, Yinchuan, Ningxia, P. R. China Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, Ningxia, P. R. China Department of Endocrinology, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong, P. R. China. ) - 出处: Spine 2019 Vol.44 No.12 PE715-E722
- 摘要: Study Design: A randomized, double-blind, controlled trial.Objective: Few studies have investigated the changes in mitochondrial dynamics in spinal co
- 扈启宽,男,汉,1964年1月生于河北省,群众,教授,博士生导师。1989年获北京大学生物系理学硕士学位,2009年1月获得北京大学博士学位,现任生理学系主任,兼任中国生理学会理事职务。出版专著1部、教材3部。发表论文30余篇,主持科研、教学课题10余项。其中,承担国基金3项,973项目4项。获宁夏自然科学优秀学术论文二等奖1项。指导研究生获得优秀硕士论文奖、优秀开题奖。