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- 作者：
丁彦才 ，刘丽 ，张红梅 ，杨涛 ，黄琦 ，马晓云 ，席海峰 ，王乔峰 ，白旺 ，李飞宇 （ 联勤保障部队第九四二医院泌尿外科；宁夏医科大学总医院医学科学研究院 ） - 出处： 中国药学杂志 2025 第60卷 第22期 P2385-2391
- 关键词： 肾纤维化 葫芦巴碱 转化生长因子-beta1 上皮-间质转化 TGF-beta1/ SMAD3信号通路
- 摘要： 目的探讨葫芦巴碱对转化生长因子-beta1诱导的肾纤维化的保护作用及其分子机制。方法通过在大鼠肾小管上皮细胞系NRK-52E中使用TGF-beta1诱导上皮-间质转化建立体外模型,并在单侧输尿管梗阻大鼠模型中模拟肾纤维化。采用蛋白免疫印迹检测纤维化标志物的表达,采用苏木精-伊红染色和马松染色检测肾组
- 作者：
丁彦才 ，刘丽 ，张红梅 ，杨涛 ，黄琦 ，马晓云 ，席海峰 ，王乔峰 ，白旺 ，李飞宇 （ 1联勤保障部队第九四二医院泌尿外科；2宁夏医科大学总医院医学科学研究院 ） - 出处： 中国药学杂志 2025 第60卷 第22期 P2385-2391
- 关键词： 肾纤维化 葫芦巴碱 转化生长因子-β1 上皮-间质转化 TGF-β1/SMAD3信号通路
- 摘要： 目的 探讨葫芦巴碱对转化生长因子-β1诱导的肾纤维化的保护作用及其分子机制。方法 通过在大鼠肾小管上皮细胞系NRK-52E中使用TGF-β1诱导上皮-间质转化建立体外模型，并在单侧输尿管梗阻大鼠模型中模拟肾纤维化。采用蛋白免疫印迹检测纤维化标志物的表达，采用苏木精-伊红染色和马松染色检测肾组织结构的
- 作者：
Wang,Guiyu ，Fan,Daiming ，Gu,Jin ，Ding,Kefeng ，Fang,Xuedong ，Shen,Lin ，Xu,Zhongfa ，Xu,Jianmin ，Cai,Jianchun ，Cai,Lianming ，Cai,Sanjun ，Chen,Gong ，Chen,Jiansi ，Cheng,Longwei ，Cheng,Yong ，Chi,Pan ，Cui,Binbin ，Dai,Guanghai ，Fu,Chuangang ，Gu,Yanhong ，He,Guodong ，Hu,Junhong ，Huang,Jing ，Huang,Rui ，Huang,Zhongcheng ，Jiang,Zheng ，Jie,Zhigang ，Ju,Haixing ，Li,Hai ，Li,Jian ，Li,Jun ，Li,Ming ，Li,Yaoping ，Li,Yunfeng ，Lin,Guole ，Liu,Haiying ，Liu,Ming ，Liu,Qian ，Pan,Zhizhong ，Peng,Yifan ，Qian,Niansong ，Qiu,Meng ，Ren,Li ，Sun,Yueming ，Tang,Jianqiang ，Tang,Qingchao ，Tang,Yuan ，Tao,Kaixiong ，Tao,Min ，Wang,Haijiang ，Wang,Meng ，Wang,Zejun ，Wang,Zhengguang ，Wang,Ziqiang ，Wang,Ziwei ，Wei,Shaozhong ，Xing,Baocai ，Xiong,Bin ，Xu,Ye ，Yan,Su ，Yang,Bin ，Yang,Chunkang ，Yao,Qinghua ，Ye,Yingjiang ，Yuan,Ying ，Zhang,Guozhi ，Zhang,Haizeng ，Zhang,Hongmei ，Zhang,Zhen ，Zhong,Yunshi ，Zhu,Ji ，Zhu,Yuan ，Zhu,Yuping ，Zou,Shuangmei ，Wang,Yuliuming ，Lv,Jingfang ，Liu,Enrui ，Yang,Ming ，Zhang,Qian ，Zhang,Weiyuan ，Zhang,Lin ，Luo,Jun ，Zheng,Zhaoxu ，Zhao,Zhixun ，Liu,Zheng ，Tao,Jinhua ，Huang,Haiyang ，Chen,Tianli ，Wang,Xishan （ 1Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;2State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, China;3Department of Gastrointestinal Surgery III, Peking University Cancer Hospital, Beijing, China;4Department of Gastrointestinal Surgery, Peking University Shougang Hospital, Beijing, China;5Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Provincial Clinical Research Center for CANCER), The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou, China;6Department of Gastrointestinal and Colorectal Surgery, The China-Japan Union Hospital of Jilin University (The Third Hospital of Jilin University), Changchun, China;7Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China;8Gastrointestinal Department of The Third Affiliated Hospital of Shandong First Medical University, Shandong, Taian, China;9Department of Colorectal Surgery, Zhongshan Hospital Fudan University, Shanghai, China;10Shanghai Engineering Research Center of Colorectal Cancer Minimally Invasive Technology, Shanghai, China;11Zhongshan Hospital Xiamen University, Xiamen, China;12Department of Abdominal Oncology Surgery, Ganzhou Cancer Hospital, Jiangxi, Ganzhou, China;13Fudan University Shanghai Cancer Center, Shanghai, China;14Department of colorectal surgery, Sun Yat-sen University Cancer Center, Guangzhou, China;15Guangxi Medical University Cancer Hospital, Nanning, China;16Jilin Cancer Hospital, Changchun, China;17Department of Gastrointestinal Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China;18Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, China;19Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, China;20Chinese PLA General Hospital, Beijing, China;21Department of General Surgery, Department of Colorectal Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;22Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China;23Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China;24Department of Colorectal Anal Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;25Cancer Hospital Chinese Academy of Medical Science, Beijing, China;26Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;27Hunan Provincial People’s Hospital, Changsha, China;28Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;29Department of digestive surgery, digestive disease hospital, the First Affiliated Hospital of Nanchang University, Nanchang, China;30Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou, China;31Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, China;32Department of GI Oncology, Laboratory of Carcinogenesis and Translational Research of the Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China;33Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;34Cancer Center, Zhejiang University, Hangzhou, China;35Beijing Cancer Hospital, Beijing, China;36Department of Colorectal & Anal Surgery, Shanxi Provincial People’s Hospital (The Fifth Clinical Medical College of Shanxi Medical University), Taiyuan, China;37Department of Colorectal surgery, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Kunming, China;38Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China;39Department of Gastrointestinal Surgery, The Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China;40Cancer Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;41Sun Yat-sen University Cancer Center, Guangzhou, China;42Gastrointestinal Center of Peking University Cancer Hospital, Beijing, China;43Department of Thoracic Oncology, Respiratory and Critical Care Medicine, the Eighth Medical Center of PLA General Hospital, Beijing, China;44Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu, China;45Department of Colorectal Surgery, Zhongshan Hospital of Fudan University, Shanghai, China;46Department of colorectal surgery, Jiangsu Province Hospital, Nanjing, China;47Department of Colorectal Surgery, Center of Cancer, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;48Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;49Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;50Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China;51Department of Gastrointestinal Surgery, the Third Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumchi, China;52Department of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Guizhou Medical University (Guizhou Cancer Hospital), Guiyang, China;53The general surgery department, The First Affiliated Hospital of Anhui Medical University, Hefei, China;54West China Medical Center, Sichuan University, Chengdu, China;55The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;56Department of Gastroenterological Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;57Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China;58Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China;59Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China;60Department of Gastrointestinal Surgery (Surgical Oncology), The Affiliated Hospital of Qinghai University, Xining, China;61Department of Colorectal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China;62Department of Gastrointestinal Surgical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fujian, Fuzhou, China;63Department of Integrated Chinese and Western Medicine, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China;64Key Laboratory of Traditional Chinese Medicine Oncology, Zhejiang Cancer Hospital, Hangzhou, China;65Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, China;66Peking University people’s Hospital, Beijing, China;67Department of Medical Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;68Department of General surgery, North China University of Science and Technology Affiliated Hospital, Tangshan, China;69Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;70Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China;71Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;72Endoscopy Center, Zhongshan Hospital of Fudan University, Shanghai, China;73Department of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China;74Department of Abdominal Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China;75Department of Colorectal Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China;76Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;77Department of Emergency Surgery, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; ） - 出处： Holistic Integrative Oncology 2023 Vol.2 No.1
- 关键词： Diagnosis Guideline Holistic integrative medicine Rectal cancer Rehabilitation management Screening Treatment
- 摘要： Purpose: Colorectal cancer is a common malignant tumor worldwide. In China, the ratio of rectal cancer to colon cancer in terms of incidence is close
- 作者：
张红梅 ，赵永萍 （ 宁夏医科大学总医院门诊部；宁夏医科大学总医院门诊部 ） - 出处： 养生保健指南 2024 第3期 P82-84
- 关键词： 慢阻肺 戒烟依从性 肺功能 生活质量
- 摘要： 目的:探索延续护理干预对慢阻肺患者戒烟依从性、患者生活质量水平及肺功能指标的影响.方法:于2021年8月-2022年3月选取我院慢阻肺患者102例,随机分为两组,对患者的戒烟依从性、肺功能指标、生活质量水平进行分析.结果:研究组的戒烟依从性、生活质量明显相对于对照组有所提高,研究组患者肺功能指标明显
- 作者：
赵永萍 ，张红梅 （ 宁夏医科大学总医院门诊部；宁夏医科大学总医院门诊部 ） - 出处： 养生保健指南 2024 第3期 P55-57
- 关键词： 延续性护理 脑卒中 偏瘫 日常生活能力 门诊
- 摘要： 目的:探讨针对门诊脑卒中偏瘫病人采用延续性护理的影响效果.方法:随机选取我院2020年2月-2022年2月期间门诊接收治疗的脑卒中偏瘫患者,作为参考对象.根据数字随分法将其分为参照组和试验组,参照组30例,试验组30例,参照组采用常规护理模式,试验组采用延续性护理模式干预,根据所得数据,对比两组患者
- 作者：
赵永萍 ，张红梅 （ 宁夏医科大学总医院门诊部；宁夏医科大学总医院门诊部 ） - 出处： 养生保健指南 2024 第2期 P73-75
- 关键词： 脑卒中 偏瘫 双向康复护理
- 摘要： 目的:针对脑卒中偏瘫患者予以门诊及家庭双向康复护理模式,分析其应用价值.方法:从我院2020年6月-2022年12月期间选取74例脑卒中偏瘫患者作为研究分析对象,按照护理方法不同,分配成观察组和对照组.对照组给予常规护理,观察组给予门诊及家庭双向康复护理模式干预,观察两组效果.结果:干预后,观察组患
- 作者：
张红梅 ，赵永萍 （ 宁夏医科大学总医院门诊部；宁夏医科大学总医院门诊部 ） - 出处： 养生保健指南 2024 第2期 P67-69
- 关键词： 健康宣教 随访护理 戒烟门诊 戒烟效果
- 摘要： 目的:探讨健康宣教联合随访护理对戒烟门诊患者的戒烟效果观察.方法:选取2020年2月至2023年2月于本院戒烟门诊就诊的1200例吸烟患者作为研究对象,随机分为观察组和对照组,每组均为600例.对照组给予传统常规护理模式干预,观察组给予健康宣教联合随访护理模式干预.记录并分析两组患者尼古丁依赖程度、
- 作者：
王慧娟 ，张红梅 （ 宁夏医科大学总医院；宁夏医科大学总医院 ） - 出处： 健康女性 2021 第50期 P231
- 关键词： 门诊 老年病人 延续优质护理 效果
- 摘要： 目的:观察门诊老年病人的延续优质护理服务以及效果.方法:在我院门诊收治的老年病人120例作为实验对象,时间在2020年4月至2021年4月.按照盲选法将患者划分为2组,每组各有60例.其中,采取常规护理干预的为对照组,采取延续优质护理服务的为观察组.就2组患者的治疗依从性进行统计,且就其生活质量和疾
期刊
- 作者：
ZHANG Hong-mei ，YAO Wei-juan ，TIAN Hui-kai ，YU He-ming ，LI Xue-jun （ Department of Pharmacology，Basic School of Medicine，Peking University；Department of Pharmacology，Ningxia medical University；Department of Rheology，Basic School of Medicine，Peking University；Deppartment of Physiology and Pathophysiology，Basic School of Medicine，Peking University；Department of Neuroscience，University of Pennsylvania；Department of Immunology，Family Planning Research insititute，Beijing ） - 出处： 中国药理学与毒理学杂志 2019 第10期 P768-769
- 摘要： The present study is designed to explore whether PTS, the main active components derived from Chinese medicine Sanqi, influence the mouse hemorheologi
期刊
- 作者：
Galbraith, Matthew D. ，Saxton, Janice ，Li, Li ，Shelton, Samuel J. ，Zhang, Hongmei ，Espinosa, Joaquin M. ，Shaw, Peter E. （ 1 School of Biomedical Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham, NG7 2UH, UK, Department of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, University of Colorado at Boulder, Boulder, CO 80309, USA, Department of Neurology, Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 90089, USA and Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China ） - 出处： Nucleic Acids Research 2013 Vol.41 No.22 P10241-10253
- 摘要： The ETS domain transcription factor Elk-1 stimulates expression of immediate early genes in response to mitogens. These events require phosphorylatio
- 张红梅，女，医学博士，1987年9月—1992年7月就读于宁夏医学院（现宁夏医科大学）临床医学系，获医学学士学位；同年考取宁夏医学院药理学教研室研究生攻读硕士学位，研究方向为“苦豆子生物碱的抗心律失常作用”，1995年7月获硕士学位并留校任教。1999年9月—2002年7月于北京大学医学部基础医学院药理系攻读博士学位，研究方向为“蛋白质组方法研究三七，灵芝等中药活性成分对血液流变学特性的影响及作用机制”。研究发现了三七活性成分的多靶点作用，为中药作用模式的研究提供了新思路。2003年4月—2006年4月于英国诺丁汉大学生物化学与细胞生物学系作博士后研究，主持BBSRC ( Biotechnology and Biology Science Research Council)资助项目：“用蛋白质组/质谱的方法鉴定c-fos SRE启动子上蛋白复合物的成分”，研究成果发表在Nuclear Acids research (IF:7.48)及Methods in Molecular Biology (IF:13.9)等杂志；2007年7月—2009年9月于日本北海道大学作访问学者，参与 了“幽门螺旋杆菌细胞毒相关A抗原（CagA）的致癌机制”的研究及CagA转基因小鼠基因型的鉴定工作；2009年10月—2010年8月访学于美国宾夕法尼亚大学药理系，参与PKC与乳腺癌转移的研究。2010年10月回宁夏医科大学药理学系工作，次年被聘为药理学系教授。回国后参与了大量的教学实践，致力于传播现代药理学的精神。主要参与的研究项目有 (1)国家自然科学基金项目“幽门螺旋杆菌CagA蛋白激活β-Catanin信号通路诱导胃癌发生的机制”；以及（2）国家自然科学基金项目：“PKC与MTDH/AEG1的相互作用与乳腺癌转移及化疗耐药的关系”。