检索结果：
返回 77 结果。
排序：
期刊
- 作者：
Man Miao,‡ ，Zhenjie Qi, ‡ ，Fengkai Sun, ，Hui Yuan, ，Xiao-Bing Lan, ，Ping Zheng, ，Jian-Qiang Yu, ，Xiaoli Guo,* ，Jian Zhang * and Zhenyu An * （ * Corresponding authors a Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Peptide & Protein Drug Research Center, School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China E-mail: anzy@nxmu.edu.cn, gxl2018666@163.com b Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China E-mail: jian.zhang@sjtu.edu.cn c School of Resource & Environment and Safety Engineering, Jining University, Shandong 273100, China ） - 出处： Organic Chemistry Frontiers 2025 Vol.12 No.9 P3058-3064
- 摘要： A convenient methodology for the synthesis of benzo[c]naphthyridinone derivatives was developed via a Rh-catalyzed and Cu-oxidized annulation of 3-dia
期刊
- 作者：
Ye, Saiya ，Ma, Lin ，Chi, Yannan ，Liu, Ning ，Liu, Yue ，Wei, Wei ，Niu, Yang ，Zheng, Ping ，Yu, Jianqiang ，Hai, Dongmei （ aSchool of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China;bKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Yinchuan, 750004, China;cColaborative Innovation Center for Ningxia Characteristic Traditional Chinese Medicine by Ningxia Hui Autonomous Region & Education Ministry of P.R. China, Yinchuan, 750004, China;dNingxia Characteristic Traditional Chinese Medicine Moder Engineering and Technique Research Center, Yinchuan, 750004, China;eNingxia Key Laboratory of Drug Development and Generic Drug Research, Yinchuan, 750004, China;fKey Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China ） - 出处： Phytomedicine 2025 Vol.141
- 关键词： Active ingredients Acute lung injury Inflammatory Neutrophils Traditional Chinese medicines
- 摘要： Backgrounds: Acute lung injury is a lethal condition characterized by uncontrolled pulmonary inflammatory responses, with high morbidity and mortalit
- 作者：
Wang, Junyuan ，Zheng, Ping ，Yu, Jianqiang ，Yang, Xiuyan ，Zhang, Jian （ aSchool of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China;bMedicinal Chemistry and Bioinformatics Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China;cKey Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Peptide & Protein Drug Research Center, School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China ） - 出处： RSC Medicinal Chemistry 2024
- 摘要： Protein-protein interactions are fundamental to nearly all biological processes. Due to their structural flexibility, peptides have emerged as promisi
期刊
- 作者：
Chunhao Zhu ，Miaomiao Tian ，Ning Liu ，Lin Ma ，Xiaobing Lan ，Jiamei Yang ，Juan Du ，Hanxiang Ma ，Yuxiang Li ，Ping Zheng ，Jianqiang Yu ，Xiaodong Peng （ School of Basic Medical Science, Ningxia Medical University, Yinchuan, China College of Pharmacy, Ningxia Medical University, Yinchuan, China College of Pharmacy, Ningxia Medical University, Yinchuan, China College of Pharmacy, Ningxia Medical University, Yinchuan, China College of Pharmacy, Ningxia Medical University, Yinchuan, China College of Pharmacy, Ningxia Medical University, Yinchuan, China College of Pharmacy, Ningxia Medical University, Yinchuan, China Department of Anesthesiology, General Hospital of Ningxia Medical University, Yinchuan, China School of Nursing, Ningxia Medical University, Yinchuan, China College of Pharmacy, Ningxia Medical University, Yinchuan, China Ping Zheng, Jianqiang Yu, and Xiaodong Peng, College of Pharmacy, Ningxia Medical University No.1160 Shengli Street, Yinchuan 750004, Ningxia, China. College of Pharmacy, Ningxia Medical University, Yinchuan, China Ping Zheng, Jianqiang Yu, and Xiaodong Peng, College of Pharmacy, Ningxia Medical University No.1160 Shengli Street, Yinchuan 750004, Ningxia, China. School of Basic Medical Science, Ningxia Medical University, Yinchuan, China College of Pharmacy, Ningxia Medical University, Yinchuan, China Ping Zheng, Jianqiang Yu, and Xiaodong Peng, College of Pharmacy, Ningxia Medical University No.1160 Shengli Street, Yinchuan 750004, Ningxia, China. ） - 出处： Phytotherapy Research 2022 Vol.36 No.9 P3644-3661
- 关键词： analgesia chronic constriction injury IRF5/P2X4R/BDNF signalling pathway neuropathic pain nobiletin
- 摘要： Neuropathic pain is chronic pain resulting from central or peripheral nerve damage that remains difficult to treat. Current evidence suggests that nob
- 作者：
余建强 ，刘宁 ，马琳 ，兰小兵 ，杨佳美 ，赵建军 ，牛建国 ，郑萍 ，何艳萍 ，王洪波 ，王伏军 ，王方舟 ，刘悦 ，黄玉琦 ，祁雪 - 关键词： 特色药用植物 活性成分 缺血性脑卒中 癫痫 保护作用
- 摘要： 缺血性脑卒中是一种严重影响人类生命和生活质量的中枢神经系统疾病,全球患者死亡率位列第2名,具有高发病率、高致残率、高死亡率和高复发率的特点,是当今社会面临的严重公共卫生系统疾病。目前,临床治疗缺血性脑卒中最有效的治疗手段是发病后4.5h内采用阿替普酶静脉溶栓以及6h内颈内动脉及大脑中动脉血管内取栓促
- 作者：
李玉香 ，余建强 ，刘宁 ，朱春浩 ，杜娟 ，马琳 ，彭晓东 ，摆茹 ，郑萍 ，石璇 ，刘建明 ，李升荣 ，杨洋 ，张梦婷 ，王冰 - 关键词： 特色药用植物 活性成分 病理性疼痛 镇痛作用
- 摘要： 病理性疼痛是指由疾病等多种病因引起的慢性疼痛。病理性疼痛在全球普通人群中的患病率高达8%,在中国约有1.2亿患者遭受病理性疼痛困扰。长期的疼痛不仅使患者身心遭受巨大折磨,也增加了患者和社会的医疗负担。药物治疗是病理性疼痛的常规治疗方式,现有的病理性疼痛的一线治疗药物仅能缓解40%患者的症状,而二三线
- 作者：
王慧 ，兰小兵 ，郑萍 ，王晴 ，马琳 ，杨佳美 ，刘宁 ，余建强 （ 〔；苏州大学附属独墅湖医院(苏州大学医学中心)；宁夏医科大学药学院；宁夏特色中医药协同创新中心宁夏药物创新与仿制药研究重点实验室 ） - 出处： 中国药理学与毒理学杂志 2022 第2期
- 关键词： 獐牙菜苦苷 PC12细胞 氧糖剥夺再灌注 神经保护 氧化应激
- 摘要： 目的 探讨獐牙菜苦苷对PC12细胞氧糖剥夺再灌注损伤的保护作用及其机制。方法 ①将PC12细胞放入恒温缺氧箱内4 h，再置CO 2 培养箱正常培养24 h构建PC12细胞OGD/R模型。再灌注同时分别给予溶剂、Swe 0.1，1.0和10.0 μmol·L -1 或阳性对照药尼莫地平12 μmol·
-
被引量：12
期刊
- 作者：
Fei Chen ，Dan Yang ，Xiao-Yu Cheng ，Hui Yang ，Xin-He Yang ，He-Tao Liu ，Rui Wang ，Ping Zheng ，Yao Yao ，Juan Li （ School of Pharmacy, Ningxia Engineering and Technology Research Center for Modernization of Traditional Chinese Medicine, and Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University ; School of Pharmacy, Ningxia Engineering and Technology Research Center for Modernization of Traditional Chinese Medicine, and Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University ; Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital, Soochow University ; Research Center of Medical Science and Technology, Ningxia Medical University ; School of Pharmacy, Ningxia Engineering and Technology Research Center for Modernization of Traditional Chinese Medicine, and Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University ; School of Basic Medical Sciences, Ningxia Medical University ; School of Pharmacy, Ningxia Engineering and Technology Research Center for Modernization of Traditional Chinese Medicine, and Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University ; School of Pharmacy, Ningxia Engineering and Technology Research Center for Modernization of Traditional Chinese Medicine, and Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University ; School of Basic Medical Sciences, Ningxia Medical University ; School of Pharmacy, Ningxia Engineering and Technology Research Center for Modernization of Traditional Chinese Medicine, and Key Laboratory of Traditional Chinese Medicine Modernization, Ministry of Education, Ningxia Medical University ） - 出处： Biological and Pharmaceutical Bulletin 2021 Vol.44 No.11 P1688-1696
- 关键词： Astragaloside IV Alzheimer’s disease neuroinflammation cognitive impairment microglial activation reduced nicotinamide adenine dinucleotide phosphate oxidase
- 摘要： Microglial activation and neuroinflammation induced by amyloid β play pivotal roles in Alzheimer’s disease pathogenesis. Astragaloside IV is one of
- 作者：
Tian, Miao-Miao ，Li, Yu-Xiang ，Liu, Shan ，Zhu, Chun-Hao ，Lan, Xiao-Bing ，Du, Juan ，Ma, Lin ，Yang, Jia-Mei ，Zheng, Ping ，Yu, Jian-Qiang ，Liu, Ning （ 1 Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China 2 College of Nursing, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China 3 Ningxia Special Traditional Medicine Modern Engineering Research Center and Collaborative Innovation Center, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China ） - 出处： Molecules 2022 Vol.27 No.1 P255
- 关键词： epidemiology glycosides ion channels membrane receptors neuropathic pain oxidative stress transcriptional regulation
- 摘要： Neuropathic pain is a refractory disease that occurs across the world and pharmacotherapy has limited efficacy and/or safety. This disease imposes a s
- 作者：
Miao-Miao Tian ，Yu-Xiang Li ，Shan Liu ，Chun-Hao Zhu ，Xiao-Bing Lan ，Juan Du ，Lin Ma ，Jia-Mei Yang ，Ping Zheng ，Jian-Qiang Yu ，Ning Liu （ Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China College of Nursing, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China ） - 出处： Molecules 2022 Vol.27 No.255 P255
- 关键词： neuropathic pain epidemiology glycosides oxidative stress transcriptional regulation ion channels
- 摘要： Neuropathic pain is a refractory disease that occurs across the world and pharmacotherapy has limited efficacy and/or safety. This disease imposes a s
- 郑萍，女，汉族，1973年4月生于宁夏中宁县，（无党派人士），教授，硕士生导师，研究方向是心脑血管药理学。2006年毕业于宁夏医科大学临床医学专业，2016年获药理学硕士学位。自工作以来承担国家级、区级及校级多项科研及教学课题，其中主持国家自然科学基金1项（甜菜碱调控MAPK信号转导通路抑制急性心肌缺血性损伤的研究，编号851160720），共发表论文20余篇，论文获宁夏自然科学优秀学术论文二等奖1项，三等奖1项。出版教材4部。科研成果《苦参碱舒张血管及防治急性缺血性心肌损伤作用的研究》获2012年自治区科技进步奖三等奖1项。