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- 作者:
黄敏 ,杨惠芳 ,王楷栋 ,孙健 ,李江平 - 关键词: α-synuclein 百草枯 调控网络 胶质细胞 神经元
- 摘要: 环境化学物暴露引发的神经毒性可能是造成散发性帕金森病在世界范围内悄无声息蔓延的重要原因之一。百草枯作为使用广泛的农药,其长期低剂量暴露所致的神经毒性资料有限,尤其百草枯致帕金森病发生发展过程中的关键分子事件更有很多未知。因此,探索环境化学物百草枯的神经毒效应及关键机制靶点至关重要。 本课题以百草枯暴
期刊
- 作者:
Ren, Jia ,Li, Yichao ,Wang, Yuwen ,Yang, Huifang ,Buyong, Faeiza Bt ( aSchool of Chemistry and Environment, Faculty of Applied Sciences, Universiti Teknologi MARA, Selangor, Shah Alam, 40450, Malaysia;bThe Department of Occupational and Environmental Health, School of Public Health, Ningxia Medical University, Yin Chuan, China ) - 出处: Malaysian Journal of Chemistry 2025 Vol.27 No.5 P233-250
- 关键词: fishes lake Laser Direct Infrared Imaging Microplastics Yuehai Lake
- 摘要: Microplastic pollution in freshwater ecosystems poses growing threats to biodiversity and human health. This study employed laser direct infrared ima
- 作者:
章梅 ,韩晓强 ,刘琭璐 ,王燕 ,马鑫 ,熊育 ,杨惠芳 ,张娜 ( 1宁夏医科大学公共卫生学院/宁夏环境因素与慢性病控制重点实验室;2宁夏医科大学基础医学院 ) - 出处: 环境与职业医学 2025 第42卷 第12期 P1429-1437
- 关键词: 煤尘 纤维化 线粒体生物发生 过氧化物酶体增殖物激活受体-γ共激活因子-1α
- 摘要: [背景]线粒体生物发生在煤工尘肺纤维化中的作用十分关键,过氧化物酶体增殖物激活受体-γ共激活因子-1α-核呼吸因子1-线粒体转录因子A通路在调控线粒体生物发生中的作用不明,故需探究其机制。[目的]通过体内外实验,探究在大鼠煤工尘肺模型中,PGC-1α-NRF1-TFAM通路在线粒体生物发生中的作用机
- 作者:
刘小娟 ,杨惠芳 ( 宁夏医科大学公共卫生学院 ) - 出处: 宁夏医科大学学报 2025 第10期
- 关键词: 乳腺癌 社会隔离 孤独感 前瞻性队列研究
- 摘要: 目的 社会隔离和孤独感是全球范围内日益严重的公共卫生问题。本研究旨在探讨社会隔离、孤独感与女性乳腺癌发病风险之间的关联。方法 基于英国生物银行的调查数据,通过自我报告问卷评估社会隔离和孤独感,并链接癌症登记数据以确定乳腺癌病例。采用Cox比例风险模型分析社会隔离、孤独感与乳腺癌发病风险之间的关联。结
- 作者:
熊育 ,韩晓强 ,刘琭璐 ,章梅 ,马鑫 ,王燕 ,杨惠芳 ,张娜 ( 宁夏医科大学公共卫生学院;宁夏医科大学基础医学院 ) - 出处: 宁夏医科大学学报 2025 第10期
- 关键词: 矽肺 马齿苋 网络药理学 分子对接技术
- 摘要: 目的 探讨马齿苋治疗矽肺的潜在作用机制。方法 基于TCMSP、BATMAN-TCM、GeneCards等数据库收集马齿苋与矽肺靶点,建立马齿苋治疗矽肺的靶点预测网络,将共同靶点提交STRING数据库,使用Cytoscape绘制活性成分-靶点网络图,对共同靶点进行基因本体功能和京都基因与基因组百科全书
期刊
- 作者:
Min,Huang ,Qian,Cai ,Yanlong,Xu ,Muzheng,Guo ,Chendi,Zhu ,Yinyin,Li ,Kexin,Wu ,Zhijun,Zhou ,Huifang,Yang ( The Department of Occupational and Environmental Health, Lab of Molecular Toxicology, School of Public Health, Ningxia Medical University, Yinchuan, China. '(1)' ; School of Public Health, MOE Key Laboratory for Public Health Safety, Key Lab of Health Technology Assessment of National Health Commission, Fudan University, Shanghai, China. [2] ) - 出处: Environmental toxicology 2019 Vol.34 No.4 P548-555
- 关键词: Paraquat cytokines tight junction proteins vascular endothelial cells
期刊
- 作者:
Yiman Li ,Yiman Li ,Yiman Li ,Yiman Li ,Huifang Yang ,Huifang Yang ,Kristina Sundquist ,Kristina Sundquist ,Kristina Sundquist ,Kristina Sundquist ,Jan Sundquist ,Jan Sundquist ,Jan Sundquist ,Jan Sundquist ,Yuhong Zhang ,Yuhong Zhang ,Xinjun Li ,Xinjun Li ( 1School of Public Health, Ningxia Medical University, Yinchuan, China;2Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, China;3Center for Primary Health Care Research, Department of Clinical Sciences, Lund University, Malmö, Sweden;4University Clinic Primary Care, Skåne University Hospital, Malmö, Sweden;5Departments of Family and Community Medicine and of Epidemiology, The University of Texas Health Science Center, Houston, TX, United States;6Center for Community-Based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Shimane University, Matsue, Japan ) - 出处: Frontiers in Public Health 2025 Vol.13
- 关键词: type 2 diabetes attention-deficit/hyperactivity disorder neighborhood population-based Sweden
- 摘要: ObjectiveBoth attention-deficit/hyperactivity disorder and neighborhood deprivation have been previously associated with an increased risk of type 2
- 作者:
陈月 ,高浩轩 ,耿小喆 ,王毓雯 ,李依蔓 ,杨惠芳 ,田炜宁 ( 宁夏医科大学公共卫生学院;宁夏环境因素与慢性病控制重点实验室 ) - 出处: 宁夏医科大学学报 2025 第6期
- 关键词: 聚苯乙烯微塑料 斑马鱼 粒径效应 神经损伤
- 摘要: 目的 使用不同粒径的聚苯乙烯微塑料,探究在同一环境相关浓度下致斑马鱼成鱼的神经毒性作用。方法 根据PS-MPs的粒径将斑马鱼成鱼随机分为control组、1 μm组、10 μm组、100 μm组。暴露持续30 d后,称重并测量体长,采用qPCR方法检测斑马鱼脑组织中神经功能相关基因和凋亡关键基因的表
期刊
- 作者:
Bing Wu ,Xue-yan Tian ,Wen-si Ni ,Hao-Xuan Gao ,Yu-wen Wang ,Ling-he Zhang ,Yu-bin Li ,Yan-ling Lv ,Ya-nan Song ,Yu-cheng Yan ,Xiao-zhe Geng ,Yi-man Li ,Hui-fang Yang ,Ji Zhao ( 1College of Public Health, Ningxia Medical University, Yinchuan 750004, PR China;2Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan 750004, PR China;3Department of Toxicology, Shaanxi Provincial Key Lab of Free Radical Biology and Medicine, School of Public Health, Fourth Military Medical University, Xi'an 710032, PR China ) - 出处: Journal of Hazardous Materials 2025 Vol.496 P139287
- 摘要: Acetamiprid is a widely used neonicotinoid pesticide that can increase the risk of inducing nervous system diseases. Considering the increased exposur
期刊
- 作者:
Yuwen Wang ,Yuhong Zhang ,Kristina Sundquist ,Jan Sundquist ,Huifang Yang ,null ,Xinjun Li ( 1School of Public Health, Ningxia Medical University, Yinchuan, China;2Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, China;3Center for Primary Health Care Research, Department of Clinical Sciences, Lund University, Jan Waldenströms gata 35, 20502, Malmö, Sweden;4University Clinic Primary Care, Skåne University Hospital, Region Skåne, Sweden;5Departments of Family and Community Medicine and of Epidemiology, The University of Texas Health Science Center, Houston, TX, USA;6Center for Community-based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Matsue, Shimane University, Matsue, Japan ) - 出处: Scientific Reports 2025 Vol.15
- 关键词: Asthma Neighborhood deprivation Type 2 diabetes mellitus Sweden
- 摘要: This study aimed to investigate the potential impact of neighborhood deprivation on the incidence of type 2 diabetes mellitus among individuals with
- 杨惠芳,女,汉族,1968年1月生于宁夏石嘴山市,中共党员,教授,博(硕)士生导师。2004年毕业于四川大学华西公共卫生学院并获博士学位,历任教研室副主任、教务处副处长、研究生院书记、公卫学院书记等职。现任实验室与装备服务中心主任,兼任中国毒理学会理事、中国环境诱变剂学会理事,中国医学装备协会医学实验室装备与技术分会委员等多项职务。宁夏国内引才312人员获得者;宁夏自治区级重点学科“劳动卫生与环境卫生学科”带头人。成果获自治区科技进步三等奖1项,参与获得自治区教学成果特等奖2项。出版参加教材6部。发表论文80余篇,获宁夏自然科学优秀学术论文二等奖1项、三等奖1项。